An atlas of polygenic burden associations across the human phenome
Summary
This web application can be used to query findings from an analysis of 162 polygenic risk scores and 551 complex traits using data from the UK Biobank study1. Traits were selected based on the heritability analysis conducted by the Neale Lab2 (P<0.05). We encourage users of this resource to conduct follow-up analyses of associations to robustly identify causal relationships between complex traits.Instructions
To query results from our atlas please select parameters on the left hand side of this page before clicking the 'Search Atlas' button. This will generate results in the Tables of Results tab.
P-value threshold - Please select whether you wish to query results for using polygenic risk scores derived using SNPs based on P<5x10-05 or P<5x10-08.
There are 3 ways to query the results of our atlas depending on the Input Type selected:
Single association query - Select a polygenic risk score and a complex trait from the drop-down menus before clicking the 'Search Atlas' button. This will look up the association result for your two choices.
Polygenic risk score phenome scan - Select a polygenic risk score from the drop-down menu and click the 'Search Atlas' button. This will query the findings between your choice of polygenic risk score with all 551 complex traits from our analysis. An interactive plot3 will be generated to display -log10 p-values multiplied by the corresponding direction of effect for each result. As such, positive associations reside above -log10=0, whereras negative associations reside below. Points are grouped and coloured based on their corresponding traits subcategory as described in the legend. Horizontal red lines indicate the Bonferroni corrected threshold for conducting 551 tests (i.e. P<0.05/551=9.07x10-05).
Outcome phenome scan - Select a complex trait from the drop-down menu and click the 'Search Atlas' button. This will query the findings between all 162 polygenic risk scores in our atlas with your chosen outcome. An interactive plot3 is generated from this query as described above, except points are grouped and coloured based on the subcategory for each of the different polygenic risk scores. Also horizontal red lines reflect the Bonferroni correction for 162 tests (i.e. P<0.05/162=3.09x10-04).
The Download button can be used to download a comma-separate value (csv) file for the results you have queried.
Citation
An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome by Tom G Richardson, Sean Harrison, Gibran Hemani & George Davey Smith. eLife (2019) doi: https://doi.org/10.7554/eLife.43657