To query results from our atlas of results please select parameters on the left hand side of this page before clicking the 'Search Atlas' button. This will generate results in the Tables of Results tab which can then be downloaded using the 'Download' button once queries have been run.
There are 3 ways to query the results of our atlas:
Genome-wide analysis - A genome-wide association analysis for a selected autoimmune disease or cancer outcome. Select a Disease outcome of interest from the drop-down menu before clicking the 'Search Atlas' button. This will evaluate all genome-wide MR results for your outcome and display these interactively using a Manhattan plot4.
Cell-type effects - In-depth genetic colocalization analyses to evaluate shared causal variants between immune-cell gene expression and disease outcoems. Select a Gene and then Disease outcome from the drop-down menus before clicking the 'Search Atlas' button. This will display evidence of that the expression of your gene of interest shares a causal variants with this disease outcome using 15 immune-cell datasets. Coefficients are posterior probabilities of association (PPA) derived using the 'coloc' R package5 where a PPA>0.8 is considered evidence of a shared causal variant in this study. Comparisons across immune cell-types are visualised using barplot using the 'ggplot2' R package6.
Phenome-wide analysis - Phenome-wide association study for genetically predicted gene regulatory on X traits and outcomes. Select a Gene and click the 'Search Atlas' button. This will query genetically predicted effects for your gene of interest on all phenome-wide outcomes from our atlas and plot them interactively based on subcategories7.
Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes by Claire Prince, Ruth E Mitchell and Tom G Richardson. American Journal of Human Genetics (2021) doi: https://doi.org/10.1016/j.ajhg.2021.10.003
For any queries please contact:Tom.G.Richardson@bristol.ac.uk